New publication: Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever
Africa / AHH / Animal Diseases / Cattle / Disease Control / East Africa / ECF / ILRI / LIVESTOCKCRP / Research / Tick Unit / Vaccines

New publication: Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever

Three doses of p67C antigen generated stronger immune responses than two doses. Antibody titres and CD4+ T-cell proliferation correlated with protection against East Coast fever. The number of doses could not be reduced from three to two without compromising the protection. Continue reading

AHH / Cattle / Disease Control / ECF / ILRI / LIVESTOCK-FISH / LIVESTOCKCRP / Vaccines

Approaches to vaccination against Theileria parva and Theileria annulata

There is a great deal of similarity in the immunopathology, genomics and biology of T. parva and T. annulata. Similar protective immune responses are directed against the sporozoite and schizont stages of the parasites, and it is remarkable that many candidate sporozoite and schizont antigens are also so similar to each other. Hence, advances in development of subunit vaccines against one parasite species are likely to be readily applicable to the other. Continue reading

Africa / AHH / Animal Diseases / Cattle / East Africa / ECF / ILRI / LIVESTOCK-FISH / Vaccines

How to validate an antigen candidate for T. parva

The ECF consortium is aiming at producing a vaccine that would trigger both an antibody response and a T cell dependent response. Thanks to the whole genome sequence of Theileria parva and its annotation, we have short listed hundreds of antigen candidates, but the number of antigen candidate that can be tested in cattle is limited. How do we narrow down the list of candidates to a handful that can be studied rigorously in live experiments? Continue reading

Africa / AHH / Animal Diseases / Cattle / East Africa / ECF / ILRI / LIVESTOCK-FISH / Uncategorized / Vaccines

Can we remix the East Coast fever Muguga cocktail?

The recent meeting of the East Coast fever consortium, which brings together experts in immunology, parasitology and genomics from three continents (ILRI, Edinburgh, Antwerp, IGS, as well as the organization that produces the infection and treatment method (ITM) vaccine, provided a venue to discuss a way forward. Continue reading

Africa / AHH / Animal Diseases / Cattle / East Africa / ECF / ILRI / LIVESTOCK-FISH / Vaccines

Can cancer biology help us understand East Coast fever?

A recent review, as well as current studies in the primary literature, present examples of how cancer research can be used in the study of Theileria biology, suggesting that this might be a turning point that could revolutionize how T. parva infection is studied. Continue reading