Three doses of p67C antigen generated stronger immune responses than two doses. Antibody titres and CD4+ T-cell proliferation correlated with protection against East Coast fever. The number of doses could not be reduced from three to two without compromising the protection.
The February 2018 issue of the Animal Health Matters newsletter from HealthforAnimals features portraits of four ILRI animal health scientists who are working to develop more effective livestock vaccines.
Tremendous progress has been made over the last ten years on East Coast fever (ECF) research.
The Infection and Treatment Method (ITM) of vaccination against the apicomplexan parasite Theileria parva has been used since the early 1970s and is still the only commercially available vaccine to combat the fatal bovine disease, East Coast fever (ECF). The disease is tick-transmitted and results in annual economic losses of at least $300 million per year.
This article provides a short history of the ‘live’ vaccine (officially known as the infection-and-immunization method of immunization) protecting Africa’s cattle against the lethal cattle disease East Coast fever and names the major funding agencies critical to its development over the last four decades and its deployment in more recent years.
ILRI is a sponsor of the 12th Biennial Conference of the Society for Tropical Veterinary Medicine (STVM) and the VIII International Conference on Ticks and Tick-borne Pathogens (TTP8) to be held from 24 to 29 August 2014 in Cape Town, South Africa. ILRI will be hosting a special session on tick research on the morning of 24 August. After a temporary absence from the tick research field, ILRI is actively exploring opportunities to re-enter this research arena.