Elise Schiecka, Anne Liljandera and Joerg Joresa,b aInternational Livestock Research Institute, Box 30709, 00100, Nairobi, Kenya bInstitute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Länggass-Str. 122, Postfach 3001, Bern, Switzerland Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides (Mmm), remains one of the most important infectious diseases of cattle in sub-Saharan Africa. CBPP …
Anna Lacasta1, James Nyagwange1, Nicholas Svitek1, Samuel Oyola1, Sonal Henson1, Lucilla Steinaa1, Vish Nene1, Ine de Goeyse2, Neena Mitter3, Michael Yu3, Fred Fellouse4, Neil King5 1International Livestock Research Institute (ILRI), 2Institute for Tropical Medicine, 3Univeristy of Queensland, 4Univeristy of Toronto, 5University of Washington. East Coast fever is present in 11 countries where roughly 28 million …
Ironically, the 8th Wonder of the World, the annual wildebeest migration in east Africa, causes a recurring hardship to livestock farmers as wildebeest calving is associated with seasonal malignant catarrhal fever (MCF) outbreaks in cattle, that is often fatal. This has led to a traditional disease avoidance strategy by Maasai and other cattle owners, where …
The aim of these short and practical video productions is to improve knowledge of Rift Valley fever and its control measures. To further encourage local communities to participate in surveillance and programs working to better prevent or control the disease, the videos have also been prepared in Swahili.
Three doses of p67C antigen generated stronger immune responses than two doses. Antibody titres and CD4+ T-cell proliferation correlated with protection against East Coast fever. The number of doses could not be reduced from three to two without compromising the protection.
To support research on the biology of T. parva and the identification of additional candidate vaccine antigens, this article reports on the sporozoite proteome as defined by LC–MS/MS analysis.
Green Mountain Antibodies has signed an agreement with the International Livestock Research Institute (ILRI) of Nairobi, Kenya to produce and distribute monoclonal antibodies that detect infectious disease markers in cattle.
There is inadequate herd and community level information on the impact of CBPP and its control by vaccination to allow adequate allocation of resources for CBPP control in affected ecosystems of Kenya. A study was designed in Narok district to provide this crucial information for the Maasai ecosystem.
There is a great deal of similarity in the immunopathology, genomics and biology of T. parva and T. annulata. Similar protective immune responses are directed against the sporozoite and schizont stages of the parasites, and it is remarkable that many candidate sporozoite and schizont antigens are also so similar to each other. Hence, advances in development of subunit vaccines against one parasite species are likely to be readily applicable to the other.
The ECF consortium is aiming at producing a vaccine that would trigger both an antibody response and a T cell dependent response. Thanks to the whole genome sequence of Theileria parva and its annotation, we have short listed hundreds of antigen candidates, but the number of antigen candidate that can be tested in cattle is limited. How do we narrow down the list of candidates to a handful that can be studied rigorously in live experiments?