Africa / AHH / Cattle / CBPP / ILRI / LIVESTOCK-FISH / LIVESTOCKCRP / Vaccines

Towards improved vaccines against contagious bovine pleuropneumonia (CBPP)

Elise Schiecka, Anne Liljandera and Joerg Joresa,b aInternational Livestock Research Institute, Box 30709, 00100, Nairobi, Kenya bInstitute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Länggass-Str. 122, Postfach 3001, Bern, Switzerland Contagious bovine pleuropneumonia (CBPP), caused by Mycoplasma mycoides subsp. mycoides (Mmm), remains one of the most important infectious diseases of cattle in sub-Saharan Africa. CBPP … Continue reading

Africa / AHH / Animal Diseases / ASF / China / Disease Control / LIVESTOCK-FISH / LIVESTOCKCRP / Swine / Vaccines

Establishment of a vaccine technology platform for African swine fever as the first target

Lucilla Steinaa1, Walter Fuchs2, Hussein Abkallo1, Nicholas Svitek1, Vish Nene1, Anna Lacasta1, Nacyra Assa-Garcia3, Sanjay Vashee3 1International Livestock Research Institute (ILRI), 2Friedrich Loeffler Institute (FLI), 3J. Craig Venter Institute (JCVI). ILRI is working together with JCVI and FLI on an exciting project for the development of a platform for rapid production of attenuated African swine … Continue reading

New publication: Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever
Africa / AHH / Animal Diseases / Cattle / Disease Control / East Africa / ECF / ILRI / LIVESTOCKCRP / Research / Tick Unit / Vaccines

New publication: Immune parameters to p67C antigen adjuvanted with ISA206VG correlate with protection against East Coast fever

Three doses of p67C antigen generated stronger immune responses than two doses. Antibody titres and CD4+ T-cell proliferation correlated with protection against East Coast fever. The number of doses could not be reduced from three to two without compromising the protection. Continue reading

Africa / AHH / Cattle / CBPP / Disease Control / East Africa / ILRI / Impact Assessment / Kenya / LIVESTOCK-FISH / LIVESTOCKCRP / Pastoralism / Vaccines

Micro-economic analysis of the potential impact of contagious bovine pleuropneumonia and its control by vaccination in Narok district of Kenya

There is inadequate herd and community level information on the impact of CBPP and its control by vaccination to allow adequate allocation of resources for CBPP control in affected ecosystems of Kenya. A study was designed in Narok district to provide this crucial information for the Maasai ecosystem. Continue reading

Africa / AHH / Animal Diseases / Cattle / East Africa / ECF / ILRI / LIVESTOCK-FISH / Vaccines

How to validate an antigen candidate for T. parva

The ECF consortium is aiming at producing a vaccine that would trigger both an antibody response and a T cell dependent response. Thanks to the whole genome sequence of Theileria parva and its annotation, we have short listed hundreds of antigen candidates, but the number of antigen candidate that can be tested in cattle is limited. How do we narrow down the list of candidates to a handful that can be studied rigorously in live experiments? Continue reading

Africa / AHH / Animal Diseases / Cattle / East Africa / ECF / ILRI / LIVESTOCK-FISH / Uncategorized / Vaccines

Can we remix the East Coast fever Muguga cocktail?

The recent meeting of the East Coast fever consortium, which brings together experts in immunology, parasitology and genomics from three continents (ILRI, Edinburgh, Antwerp, IGS, as well as the organization that produces the infection and treatment method (ITM) vaccine, provided a venue to discuss a way forward. Continue reading